"From what is revealed in the magazine, there are a couple of facts that could constitute sexual abuse, but this will be determined by diligent investigation," Guerra was quoted as saying.
The cover story in Sábado, owned by the mass-circulation El Mercurio newspaper, quoted several of the women as describing pressure from López to have sex.
"He projected onto a giant screen a video showing him having sex with a famous Chilean television personality," actress and journalist Daniela Ginestar told the magazine.
Ginestar said Lopez, who is 35, had masturbated in front of her.
"I wanted to escape, but he told me that if these things shocked me I should find another line of work," she said.
Other actresses were quoted as accusing him of forcibly kissing them or making sexual propositions at film festivals, parties or even work meetings.
Well-known actress and model Josefina Montané told Sábado that in a meeting López "literally asked me if he could grab my tit."
"I thought we were just going to talk about work, but the situation ended up being extremely uncomfortable," said Montane, describing a 2014 meeting with López in Santiago. "He literally asked me if he could grab my tit."
In his apology, López said he was "in shock" and while admitting he might have acted like "a scoundrel, an imbecile," he denied being a sex pest.
The 35-year-old gained fame through his trilogy Qué pena tu vida, Qué pena tu boda and Qué pena tu familia, before in 2005 directing Santos, a film about a failed comic artist.
In April, Chilean prosecutors also opened an investigation into sexual abuse allegations against director Herval Abreu, known as the "czar" of Chilean soap operas.
Sexual abuse and harassment allegations against powerful men in a range of sectors have emerged across the globe since The New York Times revealed allegations against US movie mogul Harvey Weinstein in October.