He will be remembered as the first British man to win Wimbledon in 77 years and as a player who battled his way to the top in a golden era for the game alongside Roger Federer, Novak Djokovic and Rafael Nadal.
"Wimbledon is where I would like to stop playing, but I am not certain I am able to do that," he said.
"I've been struggling for a long time. I'm not sure I can play through the pain for another four or five months.
"Pretty much done everything that I could to try and get my hip feeling better and it hasn't helped loads."
He pulled out of last year's Australian Open to have hip surgery and only returned in June at Queen's Club in London. He ended the season at Shenzhen in September after only a handful of appearances to concentrate on working his way back to full fitness. But he was knocked out in the second round on his return at Brisbane last week and called it quits on Thursday after less than an hour of a practice match in Melbourne against Djokovic, with his movement clearly hampered.
"I think there is a chance the Australian Open is my last tournament," he said.
While he intends to begin his opening-round match against 22nd seed Roberto Bautista Agut next week, how his body withstands potentially gruelling five-set clashes in energy-sapping heat remains to be seen.
One of the so-called 'Big Four,' along with Federer, Djokovic and Nadal, who have dominated the game for years, Murray's ranking has slumped to 230.
He hasn't reached a Grand Slam final since winning his second Wimbledon title in 2016, but has nevertheless enjoyed a glittering career since turning professional in 2005, with not only three Grand Slam titles, but two Olympic gold medals and 45 ATP crowns.
"Andy, just watched your conference. Please don't stop trying. Keep fighting," he wrote.
"I can imagine your pain and sadness. I hope you can overcome this. You deserve to retire on your own terms, whenever that happens. We love you @andy_murray and we want to see you happy and doing well."
That sentiment was echoed by Belgian four-time major winner Kim Clijsters, who like many could not help but be moved by Murray's emotional announcement.
"My heart breaks listening to @andy_murray during his press conference," she tweeted.
Billie Jean King called him "a champion on and off court", referring to Murray's long-time support of women's equality in tennis.
"So sorry you cannot retire on your own terms, but remember to look to the future. Your greatest impact on the world may be yet to come. Your voice for equality will inspire future generations," she said.