"Even though we lost by 20 points [against the All Blacks], I think there's a lot of positives from the game."
As expected, flanker David Pocock and Israel Folau were named by Cheika to make their return to the starting line-up. Pocock had a neck injury and Folau trained strongly after sustaining an ankle injury in the opening Bledisloe Cup clash against New Zealand.
Folau has been named on the right wing with Dane Haylett-Petty to retain the No. 15 jersey after two strong performances at fullback.
Prop Sekope Kepu is set to earn his 97th test cap on Saturday with the veteran also named among the reserves, after missing the match-day 23 for the Wallabies' 23-18 win over South Africa last weekend.
Argentina is seeking its first win in Australia in 35 years.
Saturday's match will mark the first time Ledesma, the former Australian forwards coach, goes head-to-head against his former colleagues.
Australia: Dane Haylett-Petty, Israel Folau, Reece Hodge, Marika Koroibete, Matt Toomua, Kurtley Beale, Will Genia, David Pocock, Michael Hooper (captain), Lukhan Tui, Izack Rodda, Rory Arnold, Allan Alaalatoa, Tatafu Polota-Nau, Scott Sio.
Reserves: Folau Faingaa, Sekope Kepu, Taniela Tupou, Adam Coleman, Pete Samu, Nick Phipps, Bernard Foley, Jack Maddocks.