When River and Boca met in the round of 16 in 2015, the second leg ended in controversy in La Bombonera. Boca fans targeted rival players with pepper spray, the game was stopped, and River was awarded the victory.
"Let's take it easy," River chairman Rodolfo D'Onofrio. "Both of us have very tough adversaries."
Three-time champions River has a semi-final against Gremio, the defending champions who advanced by routing Argentine side Atlético Tucumán 6-0 on aggregate.
South America's second most prestigious cup is at the quarter-final stage, featuring three teams each from Brazil and Colombia.
Bahia and Atlético Paranaense meet in an all-Brazilian encounter. The winners will take on Fluminense of Brazil or Nacional, the Uruguayan side which surprisingly eliminated Argentine favourites San Lorenzo.
The contract was signed with company BRFOOT Midia and the values will be equally split among 18 clubs. TV Globo, Brazil's most powerful media group, owns broadcasting rights of the country's national championships.
Facebook said last week it would broadcast live matches from the Copa Libertadores next year, after reaching a four-year deal to acquire part of the rights to the biggest club tournament in South America.