Mauro Icardi's ongoing contract dispute with Inter Milan shows no sign of abating as the Italian team crashed out of the Europa League in his absence on Thursday before this weekend's key derby showdown against city rival's AC Milan at the San Siro.
Title-holders Juventus return to domestic duty against Genoa, looking to build on their 18-point advantage on top of the table, days after Cristiano Ronaldo's hat-trick rescued their Champions League campaign.
Firmly on track for an eighth consecutive Scudetto, Juventus are distantly followed by Napoli, who host Udinese, days after falling 3-1 to Salzburg in the Europa League.
Carlo Ancelotti's southerners still qualified for the quarter-finals of the second-tier European tournament which is their only hope of a trophy this season, 4-3 on aggregate.
"In Serie A we certainly are not in a comfortable position," conceded Ancelotti, who are six points ahead of AC Milan.
"We had a setback against Sassuolo (1-1 last weekend) and need to be vigilant, as if we can't have first place, we should at least hold on to second."
Claudio Ranieri's Roma can profit from the Milan sides neutralising each other as they target the Champions League.
Ranieri got off to a winning start with a 2-1 win over Empoli after taking over after Eusebio Di Francesco was sacked following their Champions League flop.
Roma are fifth, three points adrift of Inter.
A win over SPAL -- two points above the relegation zone -- would keep the Romans in the chase for elite European football next season.
"When I joined the team was coming off the back of two consecutive defeats, with lots of players out," said the 67-year-old Ranieri.
"My message to them is 'play without fear'."
Europa League hopefuls Atalanta host bottom club Chievo with Lazio at home against Parma and Sampdoria away at Sassuolo before the international break.
New Empoli coach Aurelio Andreazzoli's first game back four months after being sacked will at home against relegation rivals Frosinone.